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PsiThera raises $47.5 million Series A, names new CEO

VCXpress Editorial Team
calendar_today12/11/2025
schedule8 min read

bolt Executive Summary

  • PsiThera closed a $47.5 million Series A round. Samsara Biocapital and Lightstone Ventures led. Eric Shaff joins as new CEO.
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PsiThera raises $47.5 million Series A, names new CEO
PsiThera, Inc.

PsiThera closed a $47.5 million Series A round. Samsara Biocapital and Lightstone Ventures led. Eric Shaff joins as new CEO.

Funding details: $47.5 million (Series A)

Full Story

PsiThera raised $47.5 million in Series A financing. Samsara Biocapital and Lightstone Ventures led the equity round. Other investors include Roivant, YK Bioventures, Eurofarma Ventures, and more. The company came from a Roivant spinout and now runs independently.



Eric Shaff started as CEO. He brings experience from Seres Therapeutics. The leadership also has Woody Sherman as Founder and Chief Innovation Officer, and Camil Sayegh as Chief Scientific Officer.



The funding advances a pipeline of oral drugs for immune and inflammatory diseases. It starts with TNF superfamily programs. The company uses its QUAISAR platform with molecular dynamics and AI to model proteins and drugs.



Investors like the setup. Christina Isacson from Lightstone Ventures, now board chair, said it mixes computation and science well for tough targets. Eric Shaff said the platform sped their lead program from hit to optimization in four months. Woody Sherman said it beats limits of old methods on moving molecules.



PsiThera makes oral drugs for immune and inflammatory diseases. It uses biophysics, AI modeling, and biology to hit targets once limited to injectables. The pipeline targets TNF superfamily members for patients with those conditions.



The announcement is on the PsiThera press release.

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